Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System

Molecules within cells are segregated into functional domains to form various organelles. While some of those organelles delimited by lipid membranes demarcating their constituents, others lack a membrane enclosure. Recently, liquid-liquid phase separation (LLPS) revolutionized our view how segregation macromolecules can produce membraneless the concept LLPS has been well studied in areas soft matter physics and polymer chemistry, its significance only recently recognized field biology. It occurs typically between that have multivalent interactions. Interestingly, these features present many molecules exert key functions neurons. In this review, we cover recent topics different contexts neuronal physiology pathology.